The deceased were identified as students of Cochin University of Science and Technoly (CUSAT) and two professionals of Infopark here, who were riding the two-wheeler.
Three other CUSAT students were injured and had been admitted to a private hospital, police said. The accident occurred when the private bus hit the car in which the students were travelling and the motorbike on the Varappuzha Bridge at 1 am, they said.