The mishap took place near Bhuralkalkhapa industrial area, about seven kms from the district headquarters, when the Nagpur-bound bus coming from the opposite direction hit the jeep.
Four persons of a family, including a woman and a minor girl, were killed on the spot, Seoni Kotwali police station in-charge, Amit Vilas Dani told reporters.
Six others, including four bus passengers, were injured in the mishap, police said adding that they have admitted in the district hospital.