The four vendors who have been booked are located in Ludhiana, Hoshiarpur and Mohali districts, said an official spokesman.
Commissioner FDA and Punjab Secretary Health and Family Welfare Hussan Lal said the cases were registered against two vendors in Ludhiana and one each in Mohali and Hoshiarpur.
They have been booked under various sections of Drugs and Cosmetics Act.
Punjab had already announced to declare e-cigarettes (Electronic Nicotine Delivery System) as illegal under The Drugs and Cosmetics Act, he said.
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Ajay Singla, State Drug Controller, Punjab said e-Cigarettes contain nicotine in chemical form which is "lethal and addictive chemical".
Under Drugs and Cosmetics Act, Nicotine is allowed to be manufactured only as nicotine gums or lozenges 2mg and 4mg.
"Every other product which contained nicotine is illegal," he said.
"Punjab is the only state where implementation of Drugs and Cosmetics Act, Food Safety & Standard Act of India and Cigarette and Other Tobacco Products Act (COTPA) was being monitored monthly at state level," Rakesh Gupta, State Programme Officer, State Tobacco Control Cell, Punjab said.