The JCM will be co-chaired by External Affairs Minister Sushma Swaraj and her Nepalese counterpart Prakash Sharan Mahat, who will arrive here tomorrow on a three-day visit.
"The Joint Commission will make a comprehensive review of bilateral issues between Nepal and India," a statement from the Nepal Foreign Ministry said.
The Nepali delegation will consists of Foreign Secretary and other senior officials.
During the recent state visit of Nepal's Prime Minister Pushpa Kamal Dahal 'Prachanda' to India, both sides had agreed to hold the Joint Commission Meeting "at the earliest".
The third meeting of the Joint Commission was held in Kathmandu in 2014 after a gap of more than two decades.