The government-run Disaster and Emergency Management Presidency said the earthquake was centered in the town of Samat, in Adiyaman province. It was followed by four more temblors, the strongest measuring 4.4.
Yusuf Firat, the mayor for Samsat told private NTV television that at least five people were injured in the quake, which knocked down some buildings in the town. There was no immediate report of any fatalities.
He said the quake caused widespread panic in the town.
The quake was felt in the neighboring provinces of Gaziantep, Kilis, Batman and Sanliurfa.