The family was attacked apparently for an old enmity in Lakki Marwat district of Khyber Pakhtunkhwa bordering north and south waziristan tribal agencies.
The head of the family, a former personal secretaryof the National Assembly member Ayesha Gulalai, was also killed by motorcycle-borne armed men a few weeks ago.
The injured were rushed to district hospital while the dead bodies were handed over to relatives after post-mortem, the police said, adding that an FIR had also been registered.
For decades, the city of Peshawar, capital of the restive Khyber Pakhtunkhwa province, has faced the threat of militants, due to its proximity to the restless tribal areas and the Pakistan-Afghanistan border.
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In September, at least three policemen were killed by two Taliban gunmen in the province.
Last week, a Pakistan Army Major was killed in a shootout with militants during a raid on a terrorist hideout in the tribal region of Dera Ismail Khan.