Symphony Technology founder Romesh Wadhwani, co-founder of outsourcing firm Syntel Bharat Neerja Desai, airline veteran Rakesh Gangwal, entrepreneur John Kapoor and Silicon Valley angel investor Kavitark Ram Shriram have featured on Forbes' The Richest People In America 2016 list.
The list was topped by 60-year-old Gates who has a net worth of $81 billion.
Gates keeps pushing to save lives in the developing world through efforts to eliminate polio, attack malaria and expand childhood vaccinations as head of the world's largest private charitable foundation, the Bill & Melinda Gates Foundation, Forbes said.
Wadhwani (69) has been ranked 222nd on the list with a net worth of $3 billion.
The IIT-Mumbai and Carnegie Mellon alumnus is the chairman and CEO of Symphony Technology Group, an empire of 17 data, technology, health care and analytics companies that together take in more than $2.8 billion in annual revenue, Forbes said. Last year, Wadhwani announced that he planned to commit up to $1 billion to fund entrepreneurship initiatives in India.
Desai ranks 274th on the list, with a net worth of $2.5 billion.
Gangwal is ranked 321 on the list with a net worth of $2.2 billion. The 63-year old IIT alumnus is an airline veteran who made his fortune from InterGlobe Aviation, the parent company of his budget airline IndiGo, India's largest by market share.
Gangwal co-founded IndiGo, headquartered outside Delhi in 2006 with one aircraft. The Miami resident owns more than 40 per cent of the company and now serves as a board member, Forbes said.
Kapoor ranks 335 on the list and has a net worth of $2.1 billion.
The 73-year-old is the chairman of two drug outfits - Akorn, which specialises in "difficult-to-manufacture" prescription drugs, and Insys Therapeutics, which produces an opioid for cancer patients.
Shriram ranks 361 on the list and has a net worth of $1.9 billion. An early Google backer, Shriram, 59, has sold off most of his stock but remains on the board of its parent company, Alphabet, Forbes said. Since 2000, Shriram has been investing in young technology start-ups through his firm, Sherpalo Ventures. His portfolio includes Paperless Post, an online card and invitation service; Optimizely, which provides web and mobile app testing; and Inmobi, a mobile advertising company. In 2014, Shriram and his wife donated $61 million to engineering initiatives at Stanford University, which both of his daughters attended and where he serves as a trustee.
The list also includes the chief executive officer and founder of Amazon.com, Jeff Bezos, who ranks second with $67 billion in net worth, followed by Berkshire Hathaway Chief Executive Officer Warren Buffett on the third position with $65.5 billion, Facebook Chief Executive Officer Mark Zuckerberg on the fourth spot with a net worth of $55.5 billion, Alphabet Chief Executive Officer Larry Page (9th) with a net worth of $38.5 billion and Dell Chief Executive Officer Michael Dell on the 20th spot with $20 billion net worth.