Puerto Rican police said the incident occurred around midnight yesterday in the town of Comerio, about 19 miles southwest of San Juan.
Police said that witnesses saw a group of men pull up in a vehicle and begin firing at a crowd of people. Five men between the ages of 20 and 34 were killed, and a 17-year-old boy was injured.
Puerto Rico has struggled with a wave of crime since thousands of police officers began calling in sick to protest millions of dollars owed in overtime pay following Hurricanes Irma and Maria.
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