The mishap occurred when a Tata Indica on its way to Hyderabad from Siddipet, rammed into a milk tanker parked on the Rajiv Rahdari Road on the outskirts of Mulug mandal headquarters in Medak at around 12.30pm today.
While four passengers of the car died on the spot, one succumbed on way to hospital.
The deceased, residents of different villages of Siddipet mandal, were identified as - Padma (35), Mallava (40), Kankamma (40), Swamy (38) and car driver Srinu (35).
The Mulug Police registered a case in this connection and shifted the bodies to Area Hospital in Gajwel for postmortem.
Local MLA T Narsa Reddy and Medak district Joint Collector Dr Sharath visited the accident site.