According to the officials, a police team raided a house in Valancia Town yesterday after getting a tip-off that some criminals were present there.
Some men present in the house fired indiscriminately at the police team, critically injuring several constables.
Other members of the police team returned fire, killing one of the criminals instantly while another three escaped.
The police team issued an alert and nearby police stations set up pickets at the entry points of Valancia Town.
Also Read
Three injured policemen were taken to Jinnah Hospital, where two of them succumbed to their injuries.
Police identified the two two dead criminals as Muhammad Alamgir and Asif Baloch alias Niazi.
They said the suspects were "target killers" and wanted by Karachi Police for about 50 crimes, including target killing, extortion, kidnapping for ransom and robbery.