The mishap took place at Sinad village in Radhanpur tehsil. While the jeep was heading for Rajasthan, the truck was coming from the wrong side on the highway, said inspector R P Zala.
A Rajasthan-based family had hired the jeep to visit pilgrimage sites in Gujarat and was on its way back when the mishap took place.
The deceased, yet to be identified, included two women and three men, while the injured included two women and four men who were rushed to a hospital at Dharpur.
The truck driver fled, abandoning the truck on the spot. Further probe is on, police said.