One of the new cases is an infant in a suburb of Quetta, making it first polio case in the provincial capital in 2014 and the second in Balochistan, the Express Tribune reported.
A WHO official confirmed that one-year-old Gul Muhammed, a resident of Eastern Bypass area, has contracted the virus, adding that he had been administered polio drops during the last seven campaigns in the area.
"It is a wild type-1 polio case. He received three POV doses through routine vaccination and more than seven doses through SIAs," he said.
The second child is 16-month-old Hamid of North Waziristan.
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Two more cases from the same province are 15-month-old Marwan from Bannu and 12-month-old Shukatullah from Tank.
Pakistan already is facing travel restrictions imposed by the World Health Organisation.
Pakistan, Nigeria and Afghanistan are the countries where the polio virus is endemic.