Army spokesman Andriy Lysenko said four soldiers died when their armored vehicle hit a mine near the front line town of Avdiivka. Another was killed in an ambush at another location, Lysenko said.
Skirmishes have reportedly been increasing in recent weeks along the line of contact between the warring sides. Some diplomatic effort was made today to reach a more enduring settlement as Ukrainian and separatist representatives met for talks in the Belarusian capital of Minsk.
The political group is likely to have the most challenging task as it discusses what degree of autonomy the rebel regions could have while remaining part of Ukraine.
"What was done today is a serious step toward political resolution; it will promote the halt of shooting," said Azamat Kulakhmetov, Russia's representative to the talks.
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More than 6,000 people have died over a year of conflict fueled by an armed insurgency calling for the breakaway of Russian-speaking eastern Ukrainian regions.
Separatists have been showing off large amounts of their hardware in rehearsal for a military parade to take place later this week in their stronghold of Donetsk. The city is only a few kilometers from the front-line, so deployment of any firepower with a caliber superior to 100 mm would nominally be in violation of the cease-fire deal.
Ukrainian President Petro Poroshenko today condemned reluctance by Russian-backed rebels to pull back their weapons.
But monitors from the Organization for Security and Cooperation in Europe said in its most recent daily report Monday that Ukrainian troops, too, are failing to abide by restrictions on weapons deployments.