People started vomiting after they ate Biriyani served at a wedding function at a village in Rahim Yar Khan, some 400 kilometers from here.
They were shifted to a nearby hospital. The 50 patients include 11 children, 16 women, 13 men, a doctor said.
The condition of more than two dozen people turned serious and were shifted to another hospital.
According to initial findings, they suffered from food poisoning after eating unwholesome rice dish served to them at the wedding, the doctor said.