Fox and 50 Cent, 39, broke up in 2003 after a year of relationship. The 50-year-old actress said it was not easy dating the artist, reported Us magazine.
"He is absolutely the love of my life. I really, really cared for him and I loved him very, very much and I always will, but he just wasn't right for me.
"That's hard when you really, really love a person in your heart, you want to be with them, but you finally have to say, 'He's just not right for me'," she said.
"I wish him the best, he is amazing and baby, he's fine, but... Sometimes love ain't always right. The heart wants what it wants, but sometimes it's just not right," Fox said.