Authorities have vowed to clean up an industry plagued by favouritism and dodgy loans -- part of a broader drive against corruption in the country.
In the latest trial, the ex-chairman of Ocean Bank, Ha Van Tham, is accused of illegally approving loans worth $23 million in 2012, ultimately leading to the bank's demise and stripping him of his status as one of the country's richest men.
Some face the death penalty, according to the lengthy indictment.
The trial involves a record 50 defence lawyers and more than 700 witnesses, and is the second time the accused have appeared after a March trial was postponed for further investigation.
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Tham is accused of approving the loan to the Trung Dung real estate company without proper collateral.
The head of the real estate company, Pham Cong Danh, is currently in jail for a separate conviction of economic mismanagement.
But after Tham was arrested in 2014, most bank branches shut and the State Bank of Vietnam, the central bank, acquired Ocean Bank for USD 0.
Ocean Group is still active in real estate and hotels and services and was valued at about USD 3.5 million in 2016, according to its website.
Vietnam has already jailed dozens of bankers in other high-profile banking cases, which some see as a commitment to cleaning up the sector.
In September last year 36 former Vietnam Construction Bank employees were given jail terms of up to 30 years, after they were accused of secretly withdrawing millions of dollars from clients' accounts to use for loans or keep for themselves.
Bad debts have long plagued the banking industry. They make up some eight percent of outstanding loans, according to the state bank, though experts say the real number could be far higher.
Authorities have also targeted other sectors in their anti-corruption drive, though analysts say convictions are often driven by political infighting rather than a genuine commitment to reform.