Regarded as one of China's worst urban disasters, 14people were pulled out of the mountain of mud that engulfed the vast area of the new industrial park in south China that borders Hong Kong.
Three people were injured in the disaster.
More than 1,500 people including firemen, police and health workers are involved in the rescue operations, searching the debris for any trapped victims.
A statement on Weibo, China's micro-blogging site akin to Twitter, from the Shenzhen municipal government said the landslide also triggered an explosion at a nearby gas station.
Also Read
A nearby section of the West-to-East natural gas pipeline exploded after the landslide struck the Hengtaiyu industrial park at around 11:40 AM which resulted in ammassing of more than 100,000 square metres of debris , state-run Xinhua news agency reported.
Videos on China's social media showed vast amounts of red mud pouring into the city with huge noise around 11 AM engulfing building after building.
Rescuers evacuated more than 900 residents from the site by evening.
An area of 20,000 square metres was covered with soil, according to the Ministry of Public Security's firefighting bureau.
It rained in Shenzhen today and roads at the scene were muddy, the city'sDaily Sunshine reported.
The 22 buildings buried in the landslide included two workers' dormitories. A residential area was also situated beside the industrial park.
Chinese President Xi Jinping and Premier Li Keqiang ordered immediate rescue efforts saying no efforts should be spared to save lives.
He also said scientific rescue efforts are needed to prevent further damages.