Defying Interior Ministry's warning that police would use live ammunition against anyone threatening public buildings, thousands of Muslim Brotherhood supporters thronged streets and clashed with security forces in the capital Cairo, Ismailiya, Damietta, Alexandria and elsewhere.
At least 60 people were killed in the clashes, BBC quoted officials as saying. Twenty five deaths were reported outside Cairo, including 12 in Nile Delta cities, while 13 people died in Cairo, health and security sources said.
Officially the death toll was put at 17, but Muslim Brotherhood claimed 25 of its supporters were killed in police firing during the protests that it dubbed as "Friday of Rage".
The army deployed dozens of armoured vehicles around Cairo and blocked all roads leading to Rabia al-Adawiya, where hundreds were killed in police firing on Wednesday. Barbed wire blocked all entrances to Tahrir Square, the scene of anti-regime protests during the January 2011 revolution.