The accident took place yesterday between Bambari and Ippy in the centre of the country.
"Fifty-nine bodies were taken to the morgue at the regional hospital in Bambari and 18 (were taken) by their relatives for burial," Bambari hospital official Michel Zahandji told AFP.
Medical charity Doctors Without Borders (MSF) said around 60 injured people were being treated at the same hospital.
"It was a 10-wheel truck that was transporting tonnes of goods and people setting off for the weekly market in Maloum. It tipped over with all its cargo," said Bambari Mayor Abel Matchipata.
Also Read
The accident may have been linked to "technical failures and to (the lorry) being overloaded", the officer said, adding that an investigation had been opened to determine the cause of the accident.
Local resident Hubert Tchenebou told AFP it was not the first time an accident involving an overloaded truck had happened in the area.
"There are police and UN forces (in the area), but they let vehicles pass on which people are perched like birds," said Tchenebou, reached by telephone.
Disclaimer: No Business Standard Journalist was involved in creation of this content