The CIA-operated spy plane fired three missiles at Islami Madrassa Muktaba Darul Uloom at Thall in Hangu district of Khyber-Pakhtunkhwa province. Thall is located within the settled areas and just outside North Waziristan Agency.
According to Afghan Taliban sources, those killed included Ahmad Jan, a close aide of Haqqani network chief Sirajuddin Haqqani, and commanders Gul Marjan and Hamidullah. Five others were injured.
Today's strike was also the first since the one that killed Tehrik-e-Taliban Pakistan chief Hakimullah Mehsud on November 1. Senior leaders, including Interior Minister Chaudhry Nisar Ali Khan, had accused the US of attempting to "sabotage" talks with the Taliban by targeting Mehsud.
Pakistan Tehrik-e-Insaf, an opposition party led by former cricketer Imran Khan, described the drone attack as a "declaration of war" by the US.