Prathipadu police in East Godavari district said they arrested four persons who were travelling in the van and seized the contraband, which was stuffed inside eight gunny bags, along with Rs 1 lakh in cash.
Prathipadu circle inspector Satyanarayana said that the ganja was being smuggled from a Visakhapatnam village to a place in Warangal district.
A case was registered and the matter transferred to the excise department for initiating action under the Narcotics Act, police added.