More than 1.6 million people in poor countries died in 2016 from diarrhoea caused by contaminated water and food, while another 2.4 million succumbed to lung infections that mostly could have been prevented or treated.
Another two million mothers and newborns perished due to complications at birth that rudimentary health care could have largely avoided.
AIDS and tuberculosis each claimed more than a million lives, while malaria killed over 700,000 people, according to half-a-dozen studies published jointly in The Lancet, a leading medical journal.
The same cannot be said for viral hepatitis, which killed 1.34 million people in 2016 -- 22 percent more than in 2000, according to the World Health Organization.
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"Hepatitis deaths can be avoided," said Raquel Peck, CEO of World Hepatitis Alliance, pointing out that no global facility exists to combat the disease and that most sufferers don't even know they have it.
"Globally, only five percent of people living with viral hepatitis are aware of their condition."
Nearly 55 million people died in 2016, while 129 million were born, leaving a net gain of 74 humans on the planet.
The Japanese averaged 83.9 years, while citizens of the Central African Republic beat the odds if they make it past 50, a discrepancy of more than three decades between highest and lowest lifespans.
Nearly three quarters of all deaths in 2016 were caused by non-communicable diseases, with heart disease related to restricted blood flow -- 9.5 million deaths -- the single biggest killer of all.
That's an increase of nearly 20 percent in a decade.
Similarly, mortality due to another so-called "lifestyle" disease, diabetes, went up by more than 30 percent over the same period to 1.4 million.
Tobacco is blamed for 7.1 million of those fatalities.
Startlingly, the study finds that -- combining the two extremes of inadequate nutrition and unhealthy eating in richer communities -- poor diet is linked to one in five deaths worldwide.
"Among all forms of malnutrition, poor dietary habits -- particularly low intake of healthy foods -- is the leading risk factor for mortality," researchers concluded.
The studies, drawing from the input of 2,500 experts, also showed that one in seven people -- 1.1 billion -- are "living with mental health and substance use disorders".
Mental health services are chronically underfunded in most nations, especially in the developing world.
In China, only six percent of people coping with common mental illnesses such as depression or anxiety disorders or with substance abuse and dementia seek out a doctor, earlier research has shown.
Less than one percent of national healthcare budgets in China and India is allocated to mental health.
The global population afflicted with Alzheimer's or Parkinson's disease stood at 2.6 million worldwide in 2016, a more than 40 percent surge from only a decade earlier.
"We are facing a triad of trouble holding back many nations and communities -- obesity, conflict and mental illness, including substance abuse disorders," said Christopher Murray, director of the Institute for Health Metrics and Evaluation at the University of Washington in Seattle, which centralised and analysed the millions of data points used the studies.
Deaths attributed to conflict and terrorism -- notably in North Africa and the Middle East -- exceeded 150,000 in 2016, a jump of 140 percent compared to a decade earlier.
"These exemplar countries may provide information on successful policies that have helped to accelerate progress on health," said Murray.
In several cases, that headway stemmed in part from the rollout of antiretroviral treatments for HIV/AIDS.