The Solar Impulse leaves from Washington on a journey planned for Saturday, depending on the weather. It will take hours for the journey top speed is 73 kph and there are none of the most basic comforts of flying.
The aircraft's creators view themselves as green pioneers promoting lighter materials, solar-powered batteries and conservation as sexy and adventurous.
Theirs is the high-flying equivalent of the Tesla electric sports car. They want people to feel a thrill while saving the planet.
His father more than half a century ago first took a submarine to the deepest and most inaccessible ocean trench on Earth.
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Now, Piccard says there's no truly new place on Earth for explorers to pioneer. At 55, he's tried.
"After a conquest of the planet, the 21st Century should be about improving the quality of life," Piccard said.
Europe saw Solar Impulse first with a test flight from Switzerland and Spain to Morocco last year. This year's US flight is another trial run that's preparation for a 2015 around-the-world trip with an upgraded version of the plane.
Parts of its wings are three times lighter than paper. Its one-person cockpit is beyond tiny.
Most of the 11,000 solar cells are on the super-long wings that seem to stretch as far as a jumbo jet's. It weighs about the size of a small car, and soars at 10,000 meters with what is essentially the power of a small motorized scooter.
"We can use much less energy than we use today without the sacrifice," said Solar Impulse CEO Andre Borschberg, the plane's other pilot. "And that's really important."
Still, questions of practicality come up. "It's clearly a stunt," said John Reilly, co-director of MIT's Joint Program on the Science and Policy of Global Change. "And it's clearly an attention-grabbing stunt.