Two new studies led by University of California - Irvine using data from NASA Gravity Recovery and Climate Experiment satellites has found that a third of the world's biggest groundwater basins are in distress.
Civilisation is rapidly draining some of its largest groundwater basins, yet there is little to no accurate data about how much water remains in them, the researchers said.
The result is that significant segments of the planet's population are consuming groundwater quickly without knowing when it might run out, researchers said.
The Indus Basin aquifer of northwestern India and Pakistan is the second-most overstressed, and the Murzuk-Djado Basin in northern Africa is third.
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California's Central Valley, utilised heavily for agriculture and suffering rapid depletion, was slightly better off but still labelled highly stressed in the study.
"Given how quickly we are consuming the world's groundwater reserves, we need a coordinated global effort to determine how much is left," said UCI professor and principal investigator Jay Famiglietti, who is also the senior water scientist at NASA's Jet Propulsion Laboratory.
For the first study published in the journal Water Resources Research, researchers examined the planet's 37 largest aquifers between 2003 and 2013.
The eight worst off were classified as overstressed, with nearly no natural replenishment to offset usage.
Another five aquifers were found, in descending order, to be extremely or highly stressed, depending upon the level of replenishment in each - still in trouble but with some water flowing back into them.
By comparing their satellite-derived groundwater loss rates to what little data exists on groundwater availability, they found major discrepancies in projected "time to depletion."
"We don't actually know how much is stored in each of these aquifers. Estimates of remaining storage might vary from decades to millennia," said Alexandra Richey, lead author on both studies.