In the upcoming drama, Asin with play the female lead opposite the 37-year-old actor.
"Today starts yet another journey. First day jitters always get to me. New dawn, new day, new film. Send some love," Abhishek posted on Twitter.
Veteran actor Rishi Kapoor will play Abhishek's father in the film. "Mere Apne" is being produced by Bhushan Kumar.
Abhishek was last seen on the big screen in 2012 film "Bol Bachchan". His next release is "Dhoom 3", in which he will be seen reprising his character of ACP Jai Dixit. The film, which also stars Aamir Khan, Katrina Kaif and Uday Chopra, will hit theatres on December 20 this year.