Abiraterone, hormone therapy increase prostate cancer survival

Giving prostate cancer patients two drug treatments at once cuts the disease progression and improves their survival chance by nearly 40 per cent, according to a new research.
Led by the University of Birmingham, the research looked at using 'Abiraterone' as an additional treatment in patients with prostate cancer who were about to start long-term hormone therapy.
It found that adding Abiraterone to hormone therapy at the start of treatment improves prostate cancersurvival by 37 per cent. The results were published in the 'New England Journal of Medicine' and presented at the 2017 ASCO Annual Meeting in Chicago.
"These are the most powerful results I've seen from a prostate cancer trial - it's a once-in-a-career feeling. This is one of the biggest reductions in death I've seen in any clinical trial for adult cancers," said Nicholas James, Professor at University of Birmingham.

Abiraterone, also known as Zytiga, is a hormone therapy.
Prostate cancer cells usually depend on testosterone to grow. Standard hormone therapy blocks the action of the male sex hormone, halting the disease.

Abiraterone goes further and shuts down the production of the hormones that fuel prostate cancer's growth.
During the trial, half of the men were treated with hormone therapy while the other half received hormone therapy and Abiraterone.
Of the 1,917 men in the trial, there were 184 deaths in the combination group compared with 262 in those given hormone therapy alone.
"Abiraterone is already used to treat some men whose disease has spread but our results show many more could benefit. In addition to the improvements in survival and time without relapse, the drug reduced the rates of severe bone complications, a major problem in prostate cancer, by more than a half," James said.

"I really hope these results can change clinical practice. We are so incredibly thankful to the patients and clinical staff who have agreed to take part in this study. With their generosity, scientists can carry out research that will help save lives," James added.
The results from the trial could change the standard of care for men with prostate cancer, making Abiraterone a first-line treatment alongside hormone therapy.
The drug is usually given to men with advanced prostate cancer that has spread and has stopped responding to standard to hormone therapy, but this study shows the added benefit to patients who are about to start long-term hormone therapy.

Each year around 46,500 men are diagnosed with prostate cancer in the UK, and around 11,000 men die from the disease.
"These results could transform the treatment of prostate cancer. Abiraterone can clearly help many more prostate cancer patients than was first thought," said Sir Harpal Kumar, Cancer Research UK's chief executive.
"The STAMPEDE trial is changing the face of prostate cancer because the flexibility of the trial design means that we can investigate a number of different treatment options rapidly and in parallel, enabling scientists to get results much more quickly than they usually would," Kumar said.
"Cancer Research UK scientists first discovered Abiraterone and subsequently played a key role in its development, including funding the first clinical trials. This study adds to the importance of the drug," he said.