Research scope of the centre, to host 120-150 engineers, will include efficient data storage and processing, optimised data transfer protocols, data security and mobile data protection, said Acronis.
The company is expecting to invest more than 55 million Singaporean dollars over the next five years in R&D in the city-state.
"Our strategy focuses on global technological leadership. Acronis' research facility in Singapore will become a software R&D centre that may be one of the largest and most advanced in the region in three years from now," said Mark Shmulevich, Acronis' chief strategy and operations officer.
Kiren Kumar, Director of the Infocomms and Media Division, Singapore Economic Development Board, said: "We warmly welcome the setup of this centre and look forward to partnering Acronis in its growth."
Serguei Beloussov, CEO of Acronis, added: "For Acronis, it is a logical development. It is our way to give back to our home country and stimulate the economic development and productivity growth in Singapore, contributing to Singapore's initiative to become a Smart Nation."