The centerpiece event, the Equality March in Washington, was endorsed by virtually every major national advocacy group working on behalf of lesbian, gay, bisexual and transgender Americans.
Leaders of those groups have been embittered by several actions of President Donald Trump's administration -- including the rollback of federal guidance advising school districts to let transgender students use the bathrooms and locker rooms of their choice.
The activists also complain that Trump, although he campaigned as a potential ally of gays and lesbians, has stocked his administration with many foes of LGBT-rights advances, including Vice President Mike Pence, Attorney General Jeff Sessions, and Health and Human Services Secretary Tom Price.
"We're here, we're queer, get that Chito out of here," was among the chants directed at Trump.
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For the LGBT community nationwide, it's an emotional time. Tomorrow is the anniversary of the mass shooting a year ago in Orlando, Florida, that killed 49 people -- mostly Latinos -- at Pulse, a gay nightclub.
Among the marchers in Washington was Gil Mendez, a Puerto Rican native who traveled with his partner all the way from San Francisco to join the parade. He carried a sign that included the names of all the Pulse victims.
Also marching, and singing freedom songs along the way, was Gregory Elfers of Teaneck, New Jersey, who was with fellow members of the New York City Gay Men's Chorus.
"It's an opportunity to tell everyone we're still here, and we're not going away at all," he said.
Roughly 100 marches and rallies were planned across the US, from Portland, Maine, and Boston to Anchorage, Alaska, and Honolulu.
More than 100,000 people were expected to turn out in Los Angeles where the annual Pride Parade was renamed the ResistMarch. Activists in Casper, Wyoming, planned that city's first-ever pride parade.
She noted that Trump, breaking from the practice of Barack Obama, has declined to issue a proclamation in honor of Pride Month, and that the Trump administration has deleted questions about sexual orientation from planned federal surveys.
"If you look at their prioritization, we're really low on it," she said. "There absolutely is a resistance aspect to this march.
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