71-year-old Dhandapani complained of uneasiness and was taken to a private hospital here where he breathed his last, his media manager Mounam Ravi said in a press release here.
Dhandapani had acted in over 160 films in Tamil, Telugu, Malayalam and Kannada languages.
He was even shooting for actor-politician R Sarath Kumar's next flick "Sandamarutham" yesterday, the release said.
Various film personalities representing the South Indian Film Chamber including its President Sarath Kumar, Director A Venkatesh, Samuthrakani paid their last respects.