Depp will be seen as a guitarist in the upcoming film 'Mortdecai', where he plays both live and in the studio, reported Rolling Stones.
While the 51-year-old actor said he was grateful for those opportunities, and that he would continue to play, he wouldn't be forming The Johnny Depp Band anytime soon.
"That whole idea for me is a sickening thing, it's always just made me sick," he said.
"The luxury now is, anybody with a certain amount of of success, if you have a musical being, you can go out and start a band and capitalise on your work in other areas. But I hate the idea, 'Come see me play the guitar because you've seen me in 12 movies.' It shouldn't be (that way). You want the people who are listening to the music to only be interested in the music," Depp added.