The actress released a statement thanking her fans for supporting her but stopped short of citing the reason behind her decision.
According to New York Post, which first broke the story, Remini was put through interrogation for asking about Scientology leader David Miscavige's wife during the wedding of Tom Cruise and Katie Holmes in 2006.
Shelly reportedly hasn't been seen in public since 2007.
In her statement Remini said, "I wish to share my sincere and heartfelt appreciation for the overwhelming positive response I have received from the media, my colleagues, and fans from around the world. I am truly grateful and thankful for all your support."
A Scientology representative denied allegations.