DeVine, 30, will star in the comedy alongside Anne Hathaway and Robert De Niro, according to Deadline.
The Intern will chronicle a 70-year-old man who finds himself as an intern at a fashion website.
De Niro will play the intern, while Hathaway is set to take on the role of the successful website founder. DeVine's character is tasked with taking charge of De Niro and the other interns.
A release date for the Warner Bros Studios comedy has yet to be revealed.
DeVine is next returning to the highly-anticipated 'Pitch Perfect 2', in addition to starring in his Comedy Central series 'House Party'.