Making a stop in Antwerp, Belgium, the British singer also dedicated her entire show to the victims of the tragedy that occured at a gay nightclub.
"I'd like to start tonight by dedicating this entire show to everybody in Orlando and Pulse nightclub," the "Hello" hitmaker said and added, "The LGBTQ community... They're like my soulmates since I was really young," before starting to cry in front of the cheering crowd.
The Orlando shooting killed 50 people and injured more than 50 others, making it the deadliest mass shooting in US history and the worst act of terrorism since 2001's 9/11.