The 28-year-old singer addressed the split during her concert on Tuesday night, reported Entertainment Weekly.
"Let's not ignore the elephant in the room. Brangelina are broken up! I don't like gossiping and private lives should be private, but I feel like it's the end of an era so I'm dedicating this show tonight to them.
"It's really, really sad. I was shocked when I woke up this morning!" Adele said.
Jolie, 41, filed for divorce on Monday after two years of marriage. The couple had been in a courtship of 10 years before tying the knot in 2014.
The couple celebrated their second anniversary last month.
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