While both teams have made it to the Round of 16 stage, the lure of keeping the one-off pre-quarterfinal game at home by virtue of being group toppers, makes it a must-win for Bengaluru who trail Persipura by a point.
The visitors, on the other hand, need a draw at the most to earn home advantage going ahead.
The Blues have come a long way from the 3-1 defeat in the away leg in March where they had as many as six first-team players missing owing to national team commitments.
Coach Ashley Westwood said his team know they are up against a tough opposition in Persipura and though playing at home with a complete squad to choose from would be a big plus, the boys will have to put in a hard shift to come away with three points.
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"We've watched a few videos on them and they are a very good side. They've been in good form and with the league in Indonesia being suspended, will come into this game fresh from a little break.
But despite what's at stake, Westwood said his side would be taking the pitch sans any pressure.
"We are fortunate it isn't a League match and we've already qualified for the last 16 so we can go into the game fairly free and without putting ourselves under pressure. We can go and see how good we are which is what the AFC Cup has been about for us this year - testing ourselves."
Persipura are the only unbeaten side in the group with four wins and a draw while the sole defeat Bengaluru suffered was at the hands of the Indonesian club. The winners of Group E play the runners-up of Group G, the battle for which is still on. While the runners-up of Group E play Hong Kong club South China AA who have topped Group G.