Researchers from the Western Sydney University in Australia examined the effects of aerobic exercise on a region of the brain called the hippocampus, which is critical for memory and other brain functions.
Brain health decreases with age, with the average brain shrinking by about five per cent per decade after the age of 40.
The researchers systematically reviewed 14 clinical trials which examined the brain scans of 737 people before and after aerobic exercise programs or in control conditions.
The participants, aged between 24 and 76 years, included a mix of healthy adults, people with mild cognitive impairment such as Alzheimer's and people with a clinical diagnosis of mental illness including depression and schizophrenia.
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The results, published in the journal NeuroImage, showed that while exercise had no effect on total hippocampal volume, it did significantly increase the size of the left region of the hippocampus in humans.
"When you exercise you produce a chemical called brain- derived neurotrophic factor (BDNF), which may help to prevent age-related decline by reducing the deterioration of the brain," said Joseph Firth, from the National Institute of Complementary Medicine (NICM) at Western Sydney University.
"In other words, exercise can be seen as a maintenance programme for the brain," he added.
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