The Taliban's drive into Helmand province is the biggest test of Afghan security forces so far in the current summer "fighting season" and comes as the government is locked in a stalemate over the presidential election.
NATO's combat mission winds down by the end of this year, and Afghanistan's army and police are fighting against the Taliban with decreasing support from the US-led coalition.
At least 800 Taliban fighters launched the offensives centred on Sangin district, a hotbed of opium production and intense fighting during the 13-year insurgency.
"We are currently trying to clear those areas which the Taliban attacked five days ago.
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"We are going to intensify our offensives. We will use massive support, and air support as well. There is (already) a clear sign of a setback (for the Taliban)."
Sediqqi said that about 150 Taliban fighters had been killed so far, while local officials in Helmand said 20 police and 13 soldiers had died, as well as more than 50 civilians.
Several Afghan officials alleged that Pakistani soldiers and intelligence officers were fighting with the Taliban -- a common claim, as Kabul believes Pakistan provides covert support for the insurgency.
"Afghan forces had taken measures against the Taliban's spring offensives, but they were not prepared for the presence of Pakistani soldiers and the ISI (Inter-Services Intelligence)," said Helmand governor Mohammad Naeem.
The last US troops pulled out of Sangin only last month, handing over their remaining bases to the Afghan forces who have now taken on full responsibility for fighting the militants nationwide.
"All parties to the conflict are obliged to take all feasible precautions to protect civilians during military operations", he said.
The clashes in Helmand raised fears of instability as Afghan politics is stuck in a stalemate over the ongoing election vote count, with presidential candidate Abdullah Abdullah alleging massive fraud by his rival Ashraf Ghani.