Addressing a rare joint meeting of Congress one day after President Barack Obama hosted him in the White House, Ghani expressed a revitalized optimism about the US-Afghan relationship.
"We owe a profound debt to the 2,315 servicemen and women killed and the more than 20,000 who have been wounded in service to your country and ours," Ghani said, after receiving a warm welcome from members of the House of Representatives and the Senate.
And, while Ghani did not mention Karzai by name, he clearly signalled a desire to turn the page after a decade of fractious ties.
The Afghan leader paused to "salute and thank" the US Congress, which controls the purse strings regarding funding for overseas operations, for its role in buttressing a nation ravaged by the Taliban and poverty.
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Ghani, who took office six months ago, said Americans have provided an inspirational gift of "hope" to his nation, not only by combatting extremism but in helping more than three million girls enroll in primary schools and raising the average Afghan lifespan from just 44 years in 2002 to over 60 today.
But he stressed that while Afghans appreciated the depth of American development assistance, they were intensely committed to self-sufficiency.
"We don't want your charity," he explained. "We have no more interest in perpetuating a childish dependence than you have in being saddled with a poor family member who lacks the energy and drive to go out and find a job."