Attaullah Khogyani, spokesman for the provincial governor, says that IS-affiliated insurgents attacked the administrative headquarters in Haska Mina district at 2:00 AM today.
He says 15 IS fighters were killed and seven wounded in the battle that followed.
Hazrat Hussain Mashreqiwal, spokesman for the Nangarhar police chief, says six police officers were wounded.
Nangarhar has long been plagued by insurgent groups. Last year militants there claimed allegiance to IS and the Taliban sent fighters against them.