Sources in the Pakistan Cricket Board (PCB) said that the national selectors were not considering all-rounder Afridi for the match on September 7 as he was carrying a knee injury.
"He has undergone a MRI scan and has been advised to undergo a rehabilitation program at the national cricket academy for the next few weeks," the source said.
The source also said that Afridi, who stepped down as the national T20 captain after the World T20 Cup in April, would first be required to play a couple of matches in the final leg of the national T20 championship next month before being considered for national selection.
Afridi had to step down as captain in April after Pakistan performed poorly in the Asia Cup and World T20 in Bangladesh and India.
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He also confirmed that batsmen Umar Akmal and Ahmed Shehzad would also not be considered for the T20 in England.
"Even though the two have apologised to the Chairman of the board but the selectors are yet not ready to accept them back in the national team," the source added.
"Afridi, Shehzad and Umar will come under consideration for the West Indies series but the selectors still want more assurance that Shehzad and Umar will be on their best behaviour when they return to the team," the source stated.
The selectors are however planning to pick uncapped allrounder Ammad Butt for the T20 match in England.