Asked about the Pakistan players' reaction to a possible series between the arch-rivals in Sri Lanka next month, Afridi replied: "I think cricket should go on between Pakistan and India because it creates good contacts.
"Wherever or whenever, cricket should go on."
Top Pakistan and Indian cricket officials met in Dubai on Sunday, agreeing to play a short limited over series after getting permission from their respective governments.
India had stalled bilateral cricket with their neighbours in the aftermath of 2008 terrorists' attacks on Mumbai, which were blamed on militants based in Pakistan.
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But the series, comprising of two Tests, five one-day and two Twenty20, ran into trouble over strained relations between the two countries since the beginning of this year.
Afridi, who toured India in 1997, 1999, 2005, 2007 and 2011, said people in both the countries want to watch the game.
"Cricket should go on, it develops good relations and public from both sides want to watch the game," said Afridi. "It should be separate from politics, both teams should always be ready."
"It will be a matter of great happiness if India comes to Pakistan in this difficult time, support Pakistan and play there," said Afridi.
Pakistan have not staged international cricket, other than a short limited overs series against Zimbabwe this year, since terrorists attacks on a Sri Lankan team bus in Lahore in March 2009.
Pakistan have since been forced to play its home matches on neutral venues in the United Arab Emirates.
Afridi said Pakistan team will be ready to tour India for next year's World Twenty20 if government and Pakistan Cricket Board allow.
"We have gone to India under worse situations," said Afridi of Pakistan's 1999 tour when extremists threatened them and dug up a pitch in New Delhi.
But a national selector said there was talent in Pakistan and the board had its plans to make use of it.
Former Test bowler Sarfaraz Nawaz also felt that Afridi shouldn't worry about who would replace him.
"I think he has had his run and it is time he realizes this. No one is indispensable and there is always a replacement although it might take some time for the replacement to be groomed properly," Nawaz said.
"If he was not sure about retiring after the World T20 why announce this last year. No doubt he has given lot of service to Pakistan cricket but I think it is time for us to move on in all formats," Yousuf said.
The World T20, set to be held in India, kicks off on March 8 with a qualifying round for the associate teams, while the Super 10 round commences from March 16.