Francis' call to hope on the eve of the most joyful celebration in the Christian calendar contrasted sharply with his sharp condemnation in recent days of the attacks in Belgium and elsewhere by Islamic extremists.
Francis entered the silent and darkened basilica with just a single candle guiding him at the start of the vigil. As he reached the altar, the basilica's floodlights flipped on in a symbolic show of light after the darkness of Good Friday, which recalls Jesus' death.
"We see and will continue to see problems both inside and out. They will always be there," he said. But he insisted: "Let us not allow darkness and fear to distract us and control our hearts."
"Today is the celebration of our hope," he said. "It is so necessary today." The Easter message recalling Christ's resurrection, "awakens and resurrects hope in hearts burdened by sadness," he said.
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The lengthy vigil service included a papal baptism for 12 adults hailing from China, South Korea and other countries around the world. Early Sunday, Francis will preside over Easter Mass and offer his annual Easter blessing.
While the pope was at the Colosseum, his chief alms-giver was out on the streets of Rome giving out sleeping bags to the homeless Friday night in a show of papal support for the city's least fortunate.