AIADMK supremo J Jayalalithaa was leading by over 5,000 votes in RK Nagar in the city against her nearest rival Shimla Muthuchozhan of DMK.
Jayalalithaa's trusted lieutinant and party Treasurer O Panneerselvam was also leading in Bodinayakanur.
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AIADMK was leading in another 35 seats, while DMK was leading in 19 and its ally Congress in three and MMK in one, according to the Election Commission data.
PMK, which went alone in the election, was leading in two seats.