The struggling airline's restructuring plan made headlines around the world earlier this month when executives were manhandled by furious workers, sparking concerns that the violence was just one of the symptoms of France's overall economic and social malaise.
"Some observers always want the pot to boil over and explode. No! The conflict at Air France does not sum up the state of France," Hollande told RTL radio.
Speaking just hours before the launch of a much-watched annual gathering of unions, employers and government members, a defensive Hollande said the Air France case must not be generalised.
On October 5, Air France announced plans to cut 2,900 jobs over 2016 and 2017 after pilots rejected a proposal to work longer hours, sparking fury among employees.
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Five employees at the airline -- which merged with Dutch national carrier KLM in 2004 -- were detained and will face trial on December 2 for their alleged role in the violence.