The inaugural flight was operated by Alliance Air, the wholly-owned subsidiary of Air India, with a 48-seater ATR-42 aircraft.
The flight will operate on the sector daily except Fridays.
The flight will save passengers from Durgapur the time- consuming road journey to Kolkata and provide them air connectivity to Air India's Delhi and Mumbai flights the same evening, and accelerate growth in the region, said a release issued by the airlines.
Flights are operated mostly to tier-2 and tier-3 cities, or those which link these cities to the metro hubs, it said.