The Paris-based International Union of Medical Care and Relief Organisations, known by its French initials UOSSM, said the attack last night levelled a medical triage point it operates in rebel-held territory outside the contested city of Aleppo.
The Britain-based Syrian Observatory for Human Rights monitoring group said at least 13 people were killed in the attack, including nine militants, some of them belonging to the al-Qaeda-linked Fatah al-Sham Front.
The US office of UOSSM said two nurses and two ambulance drivers were killed and one nurse remained in a critical condition following the attack on the medical facility in Khan Touman. UOSSM said the nurse later died of her injuries.
"This is a deplorable act against health care workers and medical facilities," said Dr. Khaula Sawah, the head of UOSSM USA.
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There were no reports on who was behind the strike.
The medical facility attack follows a Monday night airstrike on a Syrian Arab Red Crescent aid convoy that prompted international condemnation and recrimination over attacks targeting humanitarian facilities and workers.
UN Secretary-General Ban Ki-moon described the convoy strike as a "sickening, savage and apparently deliberate attack." The convoy was carrying aid materials from the UN.