"Both leaders are responsible for the deaths of many innocent Afghans, and their removal will both disrupt the terrorist operations of their respective organisations and improve overall security of the country," the US command said in a statement.
According to Afghan intelligence services, and a spokesman for US forces in Kabul, "Omar Khetab, number two in the al-Qaeda network for the Indian subcontinent" was killed on Monday.
"This operation is a testament to the real growth the Afghan forces have achieved over the past year," said General John Nicholson, commander of US forces and Operation Resolute Support NATO, quoted in the statement.
The US also announced the death of the leader of the "Red Unit" -- the Taliban's "special forces" in Helmand, a southern province where insurgents control ten of its 14 districts.
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According to the spokesman, "Wali and his 'Red Unit' are responsible for planning numerous suicide bombings, IED attacks, and coordinated assaults against civilians, Afghan and coalition forces."
The statement noted: "The Taliban in Helmand province are responsible for poppy cultivation and opium trade that funds their activities."
At the end of November, the Americans began a series of raids against heroin laboratories in Helmand.
US Forces began identifying drug labs to hit after President Donald Trump's strategy announcement in August made it easier for American air power to proactively target the Taliban and its sources of revenue and infrastructure.
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