Inspired by the life of Real Housewives' Kyle Richards, the single-camera comedy is set in the 1970s amid the sexual revolution and the rise of feminism.
Silverstone, 39, will star as Bonnie Nolan, a mother with two daughters who finds herself facing an entirely new world after she leaves her husband, reported Entertainment Weekly.
"American Woman" is written by "30 Rock" alum John Riggi, who will executive produce alongside John Wells.