Batting first, South Africa A scored 275 for eight in 50 overs with Rilee Russouw scoring 137 off 150 balls with 15 boundaries with next best score being 29 by Farhan Behardien.
Leggie Karn was the most successful bowler grabbing two for 35 in 10 overs and then smashed a 16-ball-39 at crucial juncture to finish the match with a ball to spare.
Karn hit four fours and two sixes hitting some lusty blows off pacers Merchant de Lange and Kagiso Rabada to snatch a victory after India A were reduced to 234 for eight from a relatively comfortable 152 for one.
The opening pair of Uthappa and Chand put on 84 while the second wicket partnership between Chand and Manan yielded 68.
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While Chand was the slowest consuming 112 deliveries, it was Manan, who upped the ante during his 31-ball knock that had eight fours and a six.
Once the top three were dismissed, there was a middle-order with Manoj Tiwary (9), Kedar Jadhav (8), Sanju Samson (28) and Rishi Dhawan (15) getting out cheaply.
Brief Scores: South Africa A 275/8 in 50 overs (Rilee Russouw 137, Karn Sharma 2/35).
India A 276/9 in 49.5 overs (Manan Vohra 53, Unmukt Chand 52, Karn Sharma 39 no). India A won by 1 wkt.
Points: India A 5; South Africa A 0.