"We've got the final go" for the operation, an ESA spokeswoman said at mission control in Darmstadt, Germany.
A science lab bearing 10 instruments, Philae will be ordered to separate from its mother ship Rosetta at 0835 GMT and head towards Comet 67P/Churyumov-Gerasimenko, the agency said, after the last of four checks.
"Final Go/NOGO complete! We're GO for separation!!!," the Rosetta mission said in a tweet.
If all goes well, Philae will touch down about seven hours later before carrying out scientific experiments on its surface -- a double first in space history.
The USD 1.6-billion project was approved in 1993.
Rosetta, carrying Philae, was hoisted into space in 2004, but needed more than a decade to reach its target in August this year -- a six-billion-kilometre trek around the inner Solar System.